Namhlanje, sifumene umbuzo onomdla ovela kwiVelentium Medical, inkampani ebuza malunga nokubonelela kwethu ngeentambo zemagnethi ezihambelana nebhayoloji kunye neentambo zeLitz, ngakumbi ezo zenziwe ngesilivere okanye igolide, okanye ezinye izisombululo zokukhusela ezihambelana nebhayoloji. Le mfuneko inxulumene netekhnoloji yokutshaja engenazingcingo yezixhobo zonyango ezifakelwayo.
I-Tianjin Ruiyuan Electrical Equipment Co., Ltd. ikhe yadibana nemibuzo enjalo ngaphambili kwaye inike abathengi izisombululo ezikumgangatho ophezulu. I-Ruiyuan Laboratory ikwaqhube uphando olulandelayo malunga negolide, isilivere, kunye nobhedu njengezinto ezinokutyalwa kwi-bioimplants:
Kwizixhobo zonyango ezifakelwayo, ukuhambelana kwezinto eziphilayo kuxhomekeke ekusebenzisaneni kwazo nezicwili zabantu, kuquka izinto ezinje ngokuxhathisa ukugqwala, impendulo yomzimba, kunye nobuthi obuvela kwi-cytotoxicity. Igolide (Au) kunye nesilivere (Ag) zihlala zithathwa njengezinokuhambelana okuhle kwezinto eziphilayo, ngelixa ubhedu (Cu) lunokuhambelana okubi kwezinto eziphilayo, ngenxa yezi zizathu zilandelayo:
1. Ukuhambelana kweGolide (Au)
Ukungangeni kweekhemikhali: Igolide yintsimbi entle engenakukwazi ukunyibilikisa okanye ukubola kwindawo engqongileyo kwaye ayikhuphi inani elikhulu lee-ion emzimbeni.
Ukungasebenzi kakuhle kwe-immunogenicity: Igolide ayibangeli ukudumba okanye ukwaliwa kwe-immune system, nto leyo eyenza ukuba ifaneleke ukufakwa ixesha elide.
2. Ukuhambelana kwezinto eziphilayo kweSilivere (Ag)
Ipropati yokulwa neentsholongwane: Ii-ion zesilivere (i-Ag⁺) zinefuthe elibanzi lokulwa neentsholongwane, ngoko ke zisetyenziswa kakhulu kwii-implants zexesha elifutshane (ezifana nee-catheters kunye nee-wound dressing).
Ukukhululwa okulawulekayo: Nangona isilivere iya kukhupha inani elincinci lee-ion, uyilo olufanelekileyo (olufana nolwe-nano-silver coating) lunokunciphisa ubuthi, lube nemiphumo yokulwa neentsholongwane ngaphandle kokonakalisa kakhulu iiseli zomntu.
Ubuthi obunokubakho: Ubuninzi bee-ion zesilivere bunokubangela ubuthi obuvela kwi-cytotoxicity, ngoko ke kuyimfuneko ukulawula ngononophelo umthamo kunye nesantya sokukhululwa.
3. Ukuhambelana kweCopper (Cu)
Ukusebenza okuphezulu kweekhemikhali: I-Copper inyibilikiswa lula kwindawo yolwelo lomzimba (njengokwenza i-Cu²⁺), kwaye ii-ion ze-copper ezikhutshiweyo ziya kubangela ii-free radical reactions, ezikhokelela ekonakaleni kweeseli, ukwaphuka kwe-DNA, kunye nokuguquka kweproteni.
Isiphumo sokudumba: Ii-ion ze-copper zinokuvuselela inkqubo yomzimba yokuzikhusela, nto leyo ebangela ukudumba okungapheliyo okanye i-tissue fibrosis.
Ubuthi be-Neurotoxicity: Ukuqokelelana kakhulu kobhedu (njengesifo sikaWilson) kunokonakalisa isibindi kunye nenkqubo yemithambo-luvo, ngoko ke ayifanelekanga ukufakwa ixesha elide.
Ukusetyenziswa okungaqhelekanga: Ipropathi yobhedu yokulwa neentsholongwane ivumela ukuba isetyenziswe kwizixhobo zonyango zexesha elifutshane (ezifana neengubo zomphezulu ezilwa neentsholongwane), kodwa ubungakanani bokukhululwa kufuneka bulawulwe ngokungqongqo.
Isishwankathelo esiPhambili
| Iimpawu | Igolide(IsiNgesi)AU） | Isilivere (Ag) | I-Copper (Cu) |
| Ukumelana nokugqwala | Inamandla kakhulu (ayisebenzi) | Phakathi (Ukukhululwa kancinci kwe-Ag+) | Ibuthathaka (Ukukhululwa lula kweCu²+) |
| Impendulo yomzimba yokuzikhusela | Phantse akukho nanye | Iphantsi (Ixesha elilawulwayo) | Phezulu (Okubangela ukudumba) |
| Ityhefu yeCto | Akukho nanye | Iphakathi-phezulu (Kuxhomekeke ekugxininiseni) | Phezulu |
| Iindlela eziphambili zokusetyenziswa | Ii-electrode/ii-prostheses ezifakwe ixesha elide | Izinto ezifakelwayo ezilwa neentsholongwane zexesha elifutshane | Ayiqhelekanga (Ifuna unyango olukhethekileyo) |
Isiphelo
Igolide nesilivere zikhethwa kakhulu kwizixhobo zokufakelwa kwezonyango ngenxa yokuba azinakonakala kakhulu kwaye zinefuthe elilawulekayo kwibhayoloji, ngelixa umsebenzi weekhemikhali zekopolo kunye nobuthi buthintela ukusetyenziswa kwayo kwizixhobo zokufakelwa zexesha elide. Nangona kunjalo, ngokuguqulwa komphezulu (njengokugquma i-oxide okanye ukuxuba), ipropati yobhedu yokulwa neentsholongwane ingasetyenziswa nakwizinga elithile, kodwa ukhuseleko kufuneka luhlolwe ngokungqongqo.
Ixesha leposi: Julayi-18-2025
